Multiple system atrophy
neurodegenerative disorder characterized by autonomic failure, parkinsonism, cerebellar impairment and corticospinal signs, with a median survival of 6-9 years
Multiple system atrophy (MSA) is a rare neurodegenerative disorder[1] which causes autonomic dysfunction, tremors, slow movement, muscle rigidity, and postural instability due to dysfunction of the basal ganglia, and ataxia.
| Multiple system atrophy | |
|---|---|
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| Alpha synuclein immunohistochemistry of the brain showing many glial inclusions | |
| Medical specialty | Neurology  |
This is caused by progressive degeneration of neurons in several parts of the brain including the basal ganglia, inferior olivary nucleus, and cerebellum.
The symptoms are closely related to Parkinson's disease.
